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503 Why is there so much disagreement regarding how life originated? by 3 Comments Last Post: by
372 Can prebiotic evolution occur in a different environment and transported to an environment conducive for the origin of life? by 1 Comments Last Post: None
289 How tight can one chemically constrain life's origins. by 3 Comments Last Post: by
136 How did the essential features of cellular life (i.e., membranes, metabolism, genetics) first arise and in what order? by 11 Comments Last Post: by
134 What is the origin of the genetic code? by 10 Comments Last Post: by
133 Given that there are almost no decent ways to answer many of the above questions are there some questions in origins of life research to which we must answer uniformly with agnosticism, and where research into such questions is bound to be fruitless? by 9 Comments Last Post: by
132 How do different sets of amino acids, of varying sizes, impact functionality? by 8 Comments Last Post: by
131 We know that we can expand the genetic alphabet. How do different alphabet sizes impact functionality? by 2 Comments Last Post: by
130 Is it possible that life emerged in a non-aqueous solvent? by 8 Comments Last Post: by
129 What where the earliest sugars in life? Did life start with glucose and ribose, or are these “next generation” sugars? by 5 Comments Last Post: by
128 Can we produce a model chemical system that demonstrates the spontaneous formation of biopolymers or plausible pre-biopolymers from plausible prebiotic molecules? by 4 Comments Last Post: by
127 How much have the biopolymers evolved, in chemical structure, from their possible ancestors? Was RNA preceded by a simpler informational polymer? Were proteins preceded by different polymers (e.g., polyesters)? by 7 Comments Last Post: by
126 What were the molecular building blocks that gave rise to the first biopolymers? by 5 Comments Last Post: by
111 Why, and how did life settle on L-amino acids and D-nucleic acids? And what are the prospects for finding life of opposite "handedness" elsewhere in the universe? by 10 Comments Last Post: by
104 When and how did metabolic cycles emerge? by 9 Comments Last Post: by
102 What features of modern life reflect prebiotic evolution and the environment in which it took place? by 5 Comments Last Post: by
101 Which biochemical features of life as we know it are universal and which were determined by the historical contingencies of its origin? by 7 Comments Last Post: by
100 Does life require membranes, genomes, and a genotype/phenotype separation? by 11 Comments Last Post: by